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Margaret Price Lady Downing was born to Reverend Price of Barrington in Gloucestershire.
On 17 May 1750 Jacob Garrard Downing 4th Baronet (age 33) and Margaret Price Lady Downing were married. She by marriage Lady Downing of East Hatley in Cambridgeshire.
On 06 Feb 1764 [her husband] Jacob Garrard Downing 4th Baronet (age 47) died without issue at Hill Street, Berkeley Square. Baronet Downing of East Hatley in Cambridgeshire extinct. The will of George Downing 3rd Baronet stated the estate should be left to establish a Cambridge college in his name if Jacob Garrard Downing 4th Baronet had no son. Jacob Garrard Downing 4th Baronet, however, left the estate to his widow Margaret Price Lady Downing leading to forty years of litigation.
On 04 Jun 1768 [her future husband] George Bowyer 5th and 1st Baronet (age 28) and Henrietta Brett Lady Bowyer (age 15) were married.
On 11 Sep 1768 George Bowyer 5th and 1st Baronet (age 28) and Margaret Price Lady Downing were married. No issue.
On 18 Sep 1778 Margaret Price Lady Downing died.
In 1799 [her former brother-in-law] William Bowyer 4th Baronet (age 63) died. His brother [her former husband] George (age 58) succeeded 5th Baronet Bowyer of Denham Court. Margaret Price Lady Downing by marriage Margaret Price Lady Downing.
On 06 Dec 1800 [her former husband] George Bowyer 5th and 1st Baronet (age 60) died at Radley Hall, Oxfordshire. His son George (age 17) succeeded 6th Baronet Bowyer of Denham Court, 2nd Baronet Bowyer of Radley.